THE NEW GENERATION
OF BIOLOGICAL MATRICES

Exaflex membranes manufactured by Maggi srl in Via Tetti Castagno 5/A 10020 Andezeno (TO) is CE certified (Notified Body ref 0373)

WHAT IS IT?

Exaflex is a membrane obtained by processing bovine pericardium of under 20 months old males from selected breeds. Their environment and their diet are strictly monitored during their growth1.

OUR SECRET IS THE BILAYER STRUCTURE

Exaflex is designed solely for use in Reconstructive Breast Surgery and manufactured according to a proprietary process that does not affect the extraordinary characteristics of the pericardium.
Exaflex guarantees rapid integration times with intrinsic cellular growth, minimal inflammation and negligible serum production2.
Each layer performs a specific task in the integration process:
The fibrillary layer: highly porous, accommodates cells and, together with the matrix components, teams up with cytokines and growth factors for immediate revitalization and early neo-angiogenesis3.
The compact layer: rapidly repopulated by fibroblasts and VEGF; it shows no accumulation of inflammatory or giant cells44. It is conceived to provide solid structural support.

THE THREE PHASES OF INTEGRATION

The Bilayer membrane undergoes revitalization by connective tissue in 3 phases:5:

During implantation collagen matrices absorb blood, the
revitalization process begins immediately and it is marked by a controlled and short-lived inflammatory phase.

Fibroblasts synthesise collagen, triggering the growth of new blood vessels to meet metabolic demand.

This phase of the reparative process is marked by the
proliferation of cells which will encourage the growth of new tissue. The remodelling phase gets also under way: the collagen synthesis turns the membrane into an integrated living tissue.

A PRO-HEAL ELEMENTS TEAM

The cell-friendly manufacturing method preserves the active components of the repair process such as proteoglycans, hyaluronic acid, fibronectin, elastin and native collagen within the membrane6.
They provide a natural reservoir of bioactive elements, which contribute to the revitalization process by controlling inflammation as well as promoting cell proliferation and migration.
Whilst maintaining biomechanical properties, they also reduce the amount of implanted biological mass needed7 (up to 50% less than dermal matrices) and promote integration even when poor blood supply occurs.

*1-7 data on file
The bovine pericardial patch in breast reconstruction: a case report.
Semprini G1, Cattin F, De Biasio F, Cedolini C, Parodi PC.
Acellular bovine pericardium in implant-based breast reconstruction: A systematic review of the literature
Uppara Mallikarjuna Minahil Mujahid Richard Pilkington M Shaheer Pervaz Mujahid
Biological and synthetic mesh use in breast reconstructive surgery: a literature review
Hugh Logan Ellis Oluwatosin Asaolu Vivien Nebo Abdul Kasem1
Impact on quality of life with breast reconstructive surgery after mastectomy for breast cancer.
Trejo-Ochoa JL1, Maffuz-Aziz A, Said-Lemus FM, Dominguez-Reyes CA, Hernández-Hernández B, Villegas-Carlos F, Rodríguez-Cuevas S.
Immediate breast reconstruction does not increase postmastectomy pain
Julia R. Henderson Amy Tao Cliona C. Kirwan Lester Barr

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